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KMID : 0617220020130010095
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Duksung Bulletin Phamaceutical Sciences
2002 Volume.13 No. 1 p.95 ~ p.98
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Effect of Crystal Form on in Vivo Topical Anti-Inflammatory Activity of Corticosteroids
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Sohn Young-Taek
Kim Sun-Young
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Abstract
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The aim of this study was to gain information on the effects of the crystal form of corticosteroids on the topical anti-inflammatory activity. Two different crystal forms, Form A and Form B, of the drugs of prednicarbate, hydrocortisone, betamethasone 17-valerate, prednisolone, and methyl prednisolone were prepared and their topical anti-inflammatory activities were measured using arachidonic acid induced ear edema assay in mice. Two crystal forms of the drugs showed differences in anti-inflammatory activity. Among the dugs examined, Form B of prednicartbate and betamethasone 17-valerate showed significantly more potent anti-inflammatory activities as compared to their Form A.
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